Concepedia

Do the lungs contribute to propofol elimination in patients during orthotopic liver transplantation without veno-venous bypass?

Yizhong Chen, Shengmei Zhu, Huiliang He, Jian‐Hong Xu, Suqin Huang, Qing-Lian Chen

PubMed · 2006 · 10 citations · 13 references

Abstract

Propofol is eliminated mainly by the liver, and also by extrahepatic organs. The lungs seem to be not a major site contributing to the extrahepatic metabolism of propofol in humans.

References

13

Propofol. An update on its clinical use.

Ian Smith, Paul F. White, Michael H. Nathanson et al. · PubMed · 1994 · 586 citations

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Disposition of Propofol Administered as Constant Rate Intravenous Infusions in Humans

E. Gepts, F. Camu, I. D. Cockshott et al. · Anesthesia & Analgesia · 1987 · 466 citations

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PHARMACOKINETICS OF PROPOFOL IN FEMALE PATIENTS

I. D. Cockshott, L.P. BRIGGS, Elaine Douglas et al. · British Journal of Anaesthesia · 1987 · 184 citations · Full text

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Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain

Haruhiko Hiraoka, Koujirou Yamamoto, Soutarou Miyoshi et al. · British Journal of Clinical Pharmacology · 2005 · 136 citations · Full text

EXTRAHEPATIC METABOLISM OF PROPOFOL IN MAN DURING THE ANHEPATIC PHASE OF ORTHOTOPIC LIVER TRANSPLANTATION †

P. VEROLI, Brian O’Kelly, F Bertrand et al. · British Journal of Anaesthesia · 1992 · 123 citations · Full text

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