T Regulatory Cells and TH17 Cells in Peri–Silicone Implant Capsular Fibrosis

Abstract

The authors' results indicate that silicone implants trigger a specific, antigen-driven local immune response through activated TH1/TH17 cells, suggesting that ensuing fibrosis is promoted by the production of profibrotic cytokines as a consequence of faltering function of local T regulatory cells.