Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.3K citations · Full text

Genome Instability, Novel Gene, Genetic Disorder +10

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

Marian DiFiglia, Ellen Sapp, Kathryn Chase et al. · Science · 1997 · 2.9K citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

Gregory J. Brewer, John R. Torricelli, E. K. Evege et al. · Journal of Neuroscience Research · 1993 · 2.3K citations

B27‐supplemented Neurobasal™, Neuroregeneration, Developmental Biology +15

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Chiara Zuccato, Andrea Ciammola, Dorotea Rigamonti et al. · Science · 2001 · 1.3K citations

Neurodegenerative Diseases, Wild-type Huntingtin Activity, Bdnf Production +12

Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

Laurent Gauthier, Bénédicte C. Charrin, María Borrell-Pagés et al. · Cell · 2004 · 1.1K citations · Full text

Bdnf Vesicular Transport, Cytoskeleton, Neuroscience +7