Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

Shenping Liu, Trudy H. Grossman, Tim Ocain et al. · Structure · 2000 · 340 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +12

The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.

Holly Cherwinski, Ronald G. Cohn, Ppy Cheung et al. · Journal of Pharmacology and Experimental Therapeutics · 1995 · 225 citations

Medicine, Immunology, Pharmacology +17

Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14

Malcolm J. Gardner, Shamira J. Shallom, Jane M. Carlton et al. · Nature · 2002 · 186 citations

Life Sciences, Genetics, Molecular Genetics +10

The Reaction of Benzyl Halides with the Sodium Salt of 2-Nitropropane.¹ A General Synthesis of Substituted Benzaldehydes

H. B. Hass, Myron L. Bender · Journal of the American Chemical Society · 1949 · 174 citations

Natural Sciences, Chemistry, Organic Chemistry +6

Intramolecular .alpha.-amidoyl-to-aryl 1,5-hydrogen atom transfer reactions. Heteroannulation and .alpha.-nitrogen functionalization by radical translocation

Victor Snieckus, Juan Carlos Cuevas, C.P. Sloan et al. · Journal of the American Chemical Society · 1990 · 169 citations

Natural Sciences, Chemistry, Catalysis +6