Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells

Cancer Statistics, 2008

Ahmedin Jemal, Rebecca L. Siegel, Elizabeth Ward et al. · CA A Cancer Journal for Clinicians · 2008 · 10.2K citations · Full text

Cancer Statistics, Epidemiology, Cancer Epidemiology +14

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Celina G. Kleer, Qi Cao, Sooryanarayana Varambally et al. · Proceedings of the National Academy of Sciences · 2003 · 1.6K citations · Full text

Breast Oncology, Pathology, Cancer Biology +16

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

Jing Tan, Xiaojing Yang, Li Zhuang et al. · Genes & Development · 2007 · 894 citations · Full text

Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Karanam Balasubramanyam, Radhika A. Varier, Mohammad Altaf et al. · Journal of Biological Chemistry · 2004 · 807 citations · Full text

Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3

Tai-Lung Cha, Binhua P. Zhou, Weiya Xia et al. · Science · 2005 · 542 citations

Histone Modifications, Histone H3, Epigenetic Change +17