Germline activating AKT3 mutation associated with megalencephaly, polymicrogyria, epilepsy and hypoglycemia

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith et al. · Nature · 2007 · 3.1K citations · Full text

Somatic Mutation, Somatic Variant, Genetics +2

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Han Cho, James Mu, Jason K. Kim et al. · Science · 2001 · 1.8K citations

Metabolic Disorder, Homeostatic Mechanism, Glucose Homeostasis +20

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen et al. · Developmental Cell · 2006 · 1.4K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +8

Growth retardation and increased apoptosis in mice with homozygous disruption of the <i>akt1</i> gene

William S. Chen, Pei-Zhang Xu, Kathrin Gottlob et al. · Genes & Development · 2001 · 920 citations · Full text

A Mosaic Activating Mutation in <i>AKT1</i> Associated with the Proteus Syndrome

Marjorie J. Lindhurst, Julie C. Sapp, Jamie K. Teer et al. · New England Journal of Medicine · 2011 · 872 citations · Full text