Concepedia

Adenovirus-mediated gene transfer of enhanced Herpes simplex virus thymidine kinase mutants improves prodrug-mediated tumor cell killing

Rainer Wiewrodt, Kunjlata M. Amin, Michael Kiefer, Vuk P Jovanovic, Veena Kapoor, Seth Force, Michael Y. Chang, Michael Lanuti, Margaret E. Black, Larry R. Kaiser,

Cancer Gene Therapy · 2003 · 54 citations · 37 references

DOI

Concepts

References

37

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Kenneth W. Culver, Zvi Ram, Stuart Wallbridge et al. · Science · 1992 · 1.5K citations

, , +17

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Sara M. Freeman, Camille N. Abboud, Katharine A. Whartenby et al. · PubMed · 1993 · 1.1K citations

, , +10

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

Frederick L. Moolten · PubMed · 1986 · 972 citations

, , +16

A Phase III Clinical Evaluation of Herpes Simplex Virus Type 1 Thymidine Kinase and Ganciclovir Gene Therapy as an Adjuvant to Surgical Resection and Radiation in Adults with Previously Untreated Glioblastoma Multiforme

N. G. Rainov · Human Gene Therapy · 2000 · 707 citations

, , +17

A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography

Sanjiv S. Gambhir, Eileen Bauer, Margaret E. Black et al. · Proceedings of the National Academy of Sciences · 2000 · 458 citations

, , +17