CD8 is needed for development of cytotoxic T but not helper T cells

Establishment in culture of pluripotential cells from mouse embryos

Martin Evans, M. H. Kaufman · Nature · 1981 · 8.5K citations

Embryo Culture, Embryonic Stem Cell, Induced Pluripotent Stem Cell +6

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

Gail R. Martin · Proceedings of the National Academy of Sciences · 1981 · 5.7K citations

Early Mouse Embryos, Stem Cell Biology, Embryology +16

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Kirk R. Thomas, Mario R. Capecchi · Cell · 1987 · 2.4K citations

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +9

T cell tolerance by clonal elimination in the thymus

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T Cell Tolerance, Autoimmune Disease, Allergy +8

The <i>in vitro</i> development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium

Thomas Doetschman, Harald Eistetter, Margot Katz et al. · Development · 1985 · 2K citations

Vitro Developmental Potential, Basal Lamina, Cell Culture +20