The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

David S. Peterson, David Walliker, Thomas E. Wellems · Proceedings of the National Academy of Sciences · 1988 · 657 citations · Full text

Life Sciences, Genetics, Pharmacology +17

Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum

Simon J. Foote, Dennis E. Kyle, Roger K. Martin et al. · Nature · 1990 · 605 citations

Life Sciences, Genetics, Molecular Genetics +16

Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross

Thomas E. Wellems, Lindsey J. Panton, Ilya Y. Gluzman et al. · Nature · 1990 · 558 citations

Life Sciences, Genetics, Infectious Diseases +14

Lysosomes, pH and the Anti-malarial Action of Chloroquine

C. A. Homewood, D. C. Warhurst, W. Peters et al. · Nature · 1972 · 536 citations

Life Sciences, Biochemistry, Pharmacology +12

Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.

Alan F. Cowman, Denise Galatis, Jennifer K. Thompson · Proceedings of the National Academy of Sciences · 1994 · 390 citations

Life Sciences, Genetics, Molecular Genetics +15