Proceedings of the National Academy of Sciences · 1995 · 719 citations · 15 references
MedicineGeneticsMolecular GeneticsCancer GeneticsCytogeneticsMolecular OncologyCancer CytogeneticsChromosomal TranslocationsGene Fusions In CancerOncogenic Fusion GenesPediatric LeukemiasTranscription Factor OncogenesAcute LeukemiasChronic Myelomonocytic LeukemiaEts Family Transcription FactorsHematologic Malignancy FusionsLeukemia-associated Fusion GenesOncogene RearrangementsPlatelet-derived Growth Factor ReceptorsTranslocation-associated Leukemias
Chromosomal rearrangements involving band 12p13 are found in a wide variety of human leukemias but are particularly common in childhood acute lymphoblastic leukemia. The genes involved in these rearrangements, however, have not been identified. We now report the cloning of a t(12;21) translocation breakpoint involving 12p13 and 21q22 in two cases of childhood pre-B acute lymphoblastic leukemia, in which t(12;21) rearrangements were not initially apparent. The consequence of the translocation is fusion of the helix-loop-helix domain of TEL, an ETS-like putative transcription factor, to the DNA-binding and transactivation domains of the transcription factor AML1. These data show that TEL, previously shown to be fused to the platelet-derived growth factor receptor beta in chronic myelomonocytic leukemia, can be implicated in the pathogenesis of leukemia through its fusion to either a receptor tyrosine kinase or a transcription factor. The TEL-AML1 fusion also indicates that translocations affecting the AML1 gene can be associated with lymphoid, as well as myeloid, malignancy.
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Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia
Pu Liu, Susan A. Tarlé, A K Hajra et al. · Science · 1993 · 743 citations
E. Ogawa, Masato Maruyama, Hiroshi Kagoshima et al. · Proceedings of the National Academy of Sciences · 1993 · 614 citations