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Isoxazolo-[3,4-d]-pyridazin-7-(6H)-ones and their Corresponding 4,5-Disubstituted-3-(2H)-pyridazinone Analogues as New Substrates for α1-Adrenoceptor Selective Antagonists: Synthesis, Modeling, and Binding Studies

Federica Montesano, Daniela Barlocco, Vittorio Dal Piaz, Amedeo Leonardi, Elena Poggesi, Francesca Fanelli, Piero G. De Benedetti

Bioorganic & Medicinal Chemistry · 1998 · 33 citations · 15 references

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References

15

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

Bernard R. Brooks, Robert E. Bruccoleri, Barry D. Olafson et al. · Journal of Computational Chemistry · 1983 · 14.9K citations

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Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

Michael J. S. Dewar, Eve G. Zoebisch, Eamonn F. Healy et al. · Journal of the American Chemical Society · 1985 · 13.1K citations

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Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

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Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

Susanna Cotecchia, Debra A. Schwinn, R R Randall et al. · Proceedings of the National Academy of Sciences · 1988 · 566 citations · Full text

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α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

Chide Han, Peter W. Abel, Kenneth P. Minneman · Nature · 1987 · 480 citations

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