Prognostic value of plasma soluble P‐selectin and von Willebrand factor as indices of platelet activation and endothelial damage/dysfunction in high‐risk patients with hypertension: a sub‐study of the Anglo‐Scandinavian Cardiac Outcomes Trial

Abstract

Among 'high-risk' patients with hypertension, raised levels of sP-sel (platelet activation) were predictive of myocardial infarction. Levels of vWF (endothelial damage/dysfunction) were not associated with coronary events and neither marker predicted cerebrovascular or composite cardiovascular endpoints. Platelets (or P-selectin) might represent a target for novel therapies or an adjunctive aid to risk stratification in the setting of hypertension.