Accelerated protein damage in brains of PIMT+/− mice; a possible model for the variability of cognitive decline in human aging

Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice

Edward Kim, Jonathan D. Lowenson, Duncan C. MacLaren et al. · Proceedings of the National Academy of Sciences · 1997 · 290 citations

Life Sciences, Molecular Biology, Neurobiology +14

Isoaspartate in peptides and proteins: formation, significance, and analysis

Dana W. Aswad, Mallik V. Paranandi, Brandon T. Schurter · Journal of Pharmaceutical and Biomedical Analysis · 2000 · 264 citations

Life Sciences, Biochemistry, Molecular Biology +10

Partial repair of deamidation-damaged calmodulin by protein carboxyl methyltransferase.

Brett A. Johnson, Esther L. Langmack, Dana W. Aswad · Journal of Biological Chemistry · 1987 · 215 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7

Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins

Mark J. Mamula, Renelle J. Gee, James I. Elliott et al. · Journal of Biological Chemistry · 1999 · 213 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Conversion of isoaspartyl peptides to normal peptides: implications for the cellular repair of damaged proteins.

Philip N. McFadden, Steven Clarke · Proceedings of the National Academy of Sciences · 1987 · 201 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16