A short diastereoselective synthesis of the natural (2R, 3R, 4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidine

Inhibition of HIV replication by amino‐sugar derivatives

George W. J. Fleet, Abraham Karpas, Raymond A. Dwek et al. · FEBS Letters · 1988 · 348 citations · Full text

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Abraham Karpas, George W. J. Fleet, Raymond A. Dwek et al. · Proceedings of the National Academy of Sciences · 1988 · 337 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Glycoprotein Processing +13

Potent competitive inhibition of α-galactosidase and α-glucosidase activity by 1,4-dideoxy-1,4-iminopentitols: syntheses of 1,4-dideoxy-1,4-imino-d-lyxitol and of both enantiomers of 1,4-dideoxy-1,4-iminoarabinitol

George W. J. Fleet, S. J. NICHOLAS, Paul W. Smith et al. · Tetrahedron Letters · 1985 · 222 citations

Medicinal Chemistry, Biochemistry, Natural Sciences +5

Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-D-arabinitol, and fagomine

Claus H. Von der Osten, Anthony J. Sinskey, Carlos F. Barbas et al. · Journal of the American Chemical Society · 1989 · 206 citations

Antimicrobial Drug Discovery, Biosynthesis, Preparative Syntheses +13

.alpha.-Amino aldehyde equivalents as substrates for rabbit muscle aldolase: synthesis of 1,4-dideoxy-D-arabinitol and 2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine

Rebecca R. Hung, Julie A. Straub, George M. Whitesides · The Journal of Organic Chemistry · 1991 · 100 citations

Rabbit Muscle Aldolase, Biosynthesis, Bioorganic Chemistry +15