Journal of Dental Research · 2010 · 21 citations · 22 references
DentistryImmunologyMolecular GeneticsImmunogeneticsOral ImmunologyPeriodontal GeneticsCytokine Gene PolymorphismGenetic Susceptibility To PeriodontitisGenotype-phenotype Association AnalysisHaplotype AnalysisInterleukin Gene VariantsPeriodontal DiseaseGenetic Susceptibility To Periodontal DiseaseHaplotype StructureInterleukin-1 Gene PolymorphismsInterleukin-1 Gene VariantsInterleukin-1 PolymorphismsLinkage Disequilibrium AnalysisPeriodontal Disease Susceptibility GenesPeriodontitis Susceptibility
The interleukin-1 (IL-1) gene family has been associated with susceptibility to periodontal diseases, including aggressive periodontitis (AgP); however, the results are still conflicting. The present study investigated the association between IL-1 genes and AgP using 70 markers spanning the 1.1-Mb region, where the IL-1 gene family maps, and exploring both the linkage disequilibrium (LD) and the haplotype structure in a case-control study including 95 patients and 121 control individuals. No association between AgP and IL1A, IL1B, and IL1RN genes was found in either single-point or haplotype analyses. Also, the LD map of the region 2q13-14 under the Malécot model for multiple markers showed no causal association between AgP and polymorphisms within the region (p = 0.207). In conclusion, our findings failed to support the existence of a causative variant for generalized AgP within the 2q13-14 region in an Italian Caucasian population.
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Principal components analysis corrects for stratification in genome-wide association studies
Alkes L. Price, Nick J. Patterson, Robert M. Plenge et al. · Nature Genetics · 2006 · 10.7K citations