Homozygous deletions of p16INK4A/MTS1 and p15INK4B/MTS2 genes in glioma cells and primary glioma tissues

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

Manuel Serrano, Gregory J. Hannon, David Beach · Nature · 1993 · 3.7K citations

Specific Inhibition, Transcriptional Regulation, Signal Transduction +14

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Gregory J. Hannon, David Beach · Nature · 1994 · 1.9K citations

Developmental Biology, Signal Transduction, Cell Division +7

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

Tsutomu Nobori, Kaoru Miura, David Wu et al. · Nature · 1994 · 1.8K citations

Tumor Biology, Multiple Human Cancers, Medicine +8

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

Esther Schmidt, Koichi Ichimura, Guido Reifenberger et al. · PubMed · 1994 · 442 citations

Pediatric Brain Tumors, Pathology, Cdk4 Gene +20