Genetics and Molecular Biology · 2010 · 20 citations · 17 references
Metabolic DisorderGeneticsHuman PolymorphismMolecular BiologyMale Blood DonorsObesityMetabolic SyndromeBody CompositionBiostatisticsBche GeneMolecular FormsHealth SciencesBiochemistryGenetic FactorGenetic BasisBche BandEnergy MetabolismPhysiologyMetabolismMedicine
This study compared obese (N = 134) and unobese (N = 92) male blood donors, regarding the relative intensity (RI) and activity of different molecular forms (G1, G2, G4 and G1-ALB) of butyrylcholinesterase (BChE, EC 3.1.1.8) found in plasma, thereby searching for an association between these variables with obesity and SNPs of exons 1 and 4 of the BCHE gene. It was shown that obese and unobese individuals do not differ in the RI of each BChE band, even when classifying the sample into three genotypes of exons 1 and 4 of the BCHE gene (-116GG/539AA, -116GG/539AT, -116GA/539AT). Although the mean BChE activity of each band was significantly higher in obese than in unobese blood donors, the proportions of BChE bands were maintained, even under the metabolic stress associated to obesity, thereby leading to infer that this proportion is somehow regulated, and may therefore be important for BChE functions.
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Circulating Ghrelin Levels Are Decreased in Human Obesity
Matthias H. Tschöp, Christian Weyer, P. Antonio Tataranni et al. · Diabetes · 2001 · 2K citations · Full text
Structure of the gene for human butyrylcholinesterase. Evidence for a single copy
Martine Arpagaus, Matthew Kott, Kostas P. Vatsis et al. · Biochemistry · 1990 · 160 citations