Concepedia

NEUROPROTECTIVE EFFECT OF ERYTHROPOIETIN AND DARBEPOETIN ALFA AFTER EXPERIMENTAL INTRACEREBRAL HEMORRHAGE

Giovanni Grasso, Francesca Graziano, Alessandra Sfacteria, Fabio Carletti, Francesco Meli, Rosario Maugeri, Marcello Passalacqua, Francesco Certo, Marco Fazio, Michele Buemi,

Neurosurgery · 2009 · 49 citations · 41 references

DOI

Abstract

These results demonstrate that weekly administered darbepoetin alfa confers behavioral and histological neuroprotection after ICH in rats similar to that of daily EPO administration. Administration of EPO and its long-lasting recombinant forms affords significant neuroprotection in an ICH model and may hold promise for future clinical applications.

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41

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