Concepedia

Stereoselective Syntheses of Tetrahydrolipstatin and of an Analogue, Potent Pancreatic‐Lipase Inhibitors Containing a β‐Lactone Moiety

Pierre Barbier, Fernand Schmeider, Ulrich Widmer

Helvetica Chimica Acta · 1987 · 67 citations · 6 references

DOI

Concepts

Abstract

Abstract Tetrahydrolipstatin ( 1 ) and itsanalogue 2 are representatives of a new class of pancreatic‐lipase inhibtors. Two stereoselective synthetic approaches are described.

References

6

Über die Stereospezifität der α‐Alkylierung von β‐Hydroxycarbonsäureestern. Vorläufige Mitteilung

György Fráter · Helvetica Chimica Acta · 1979 · 256 citations

, , +6

(R)- and (S)-2-acetoxy-1,1,2-triphenylethanol - effective synthetic equivalents of a chiral acetate enolate

Manfred Braun, Ralf Devant · Tetrahedron Letters · 1984 · 126 citations

, , +7

Syntheses of Tetrahydrolipstatin and Absolute Configuration of Tetrahydrolipstatin and Lipstatin

Pierre Barbier, F Schneider · Helvetica Chimica Acta · 1987 · 91 citations

, , +16

The Preparation of Optically Pure 3-Hydroxyalkanoic Acid. The Enantioface-differentiating Hydrogenation of the C=O Double Bond with Modified Raney Nickel. XXXVII.

Masaaki Nakahata, Motomasa Imaida, Hiroshi Ozaki et al. · Bulletin of the Chemical Society of Japan · 1982 · 88 citations

, , +15

Enantioselective synthesis of anti-.alpha.-methyl-.beta.-hydroxy esters through titanium tetrachloride-mediated aldol condensation

Cesare Gennari, Anna Bernardi, Lino Colombo et al. · Journal of the American Chemical Society · 1985 · 80 citations

, , +8