Valproate Improves Memory Deficits in an Alzheimer’s disease Mouse Model: Investigation of Possible Mechanisms of Action

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

Christopher J. Phiel, Fang Zhang, Eric Yi‐Hsiu Huang et al. · Journal of Biological Chemistry · 2001 · 1.7K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

HDAC2 negatively regulates memory formation and synaptic plasticity

Ji‐Song Guan, Stephen J. Haggarty, Emanuela Giacometti et al. · Nature · 2009 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +14

Recovery of learning and memory is associated with chromatinremodelling

André Fischer, Farahnaz Sananbenesi, Xinyu Wang et al. · Nature · 2007 · 1.2K citations

Life Sciences, Cell Biology, Molecular Biology +10

Regulation of Histone Acetylation during Memory Formation in the Hippocampus

Jonathan M. Levenson, Kenneth J. O’Riordan, Karen Brown et al. · Journal of Biological Chemistry · 2004 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17