Concepedia

Oxali‐Titanocene Y: A Potent Anticancer Drug

James Claffey, Megan Hogan, Helge Müller‐Bunz, Clara Pampillón, Matthias Tacke

ChemMedChem · 2008 · 51 citations · 11 references

DOI

Concepts

Abstract

In three simple steps the anticancer drug bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) oxalate (oxali-titanocene Y) can be synthesised from commercially available starting materials. Oxali-titanocene Y shows twice the cytotoxicity of cisplatin in pig kidney epithelial (LLC-PK) cells and is the most cytotoxic titanocene known.

References

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