Concepedia

Experimental Hindlimb Ischemia Increases Neutrophil-Mediated Matrix Metalloproteinase Activity: A Potential Mechanism for Lung Injury After Limb Ischemia

George Plitas, Paul J. Gagne, Bart E. Muhs, I.Andreea Ianus, Jason P. Shaw, Mira Beudjekian, Yara Delgado, Glenn R. Jacobowitz, Caron Rockman, Peter Shamamian

Journal of the American College of Surgeons · 2003 · 21 citations · 16 references

DOI

Abstract

HI increases pulmonary proMMP-9, active MMP-9, and active MMP-2 levels. Neutrophil depletion blocks this effect. These data suggest that acute limb ischemia leads to PMN-mediated changes in MMP activity.

References

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, , +8

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, , +17

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