American Journal of Respiratory and Critical Care Medicine · 1998 · 229 citations · 32 references
PharmacyImmunologyToxicologyEnvironmental HealthEnvironmental ToxicologyPulmonary Function TestingEnvironmental Toxin ExposureExposure AssessmentMycotoxin ExposureMycotoxinsPulmonary ToxicologyRespiratory ToxicologyDust ExposureDust Exposure AssessmentLong-term Exposure EffectsLung Function DeclineLung Function TestingPersonal Dust Exposure AssessmentPersonal Exposure MonitoringPulmonary Function Decline
Exposure-response relationships for endotoxin as measured in dust and longitudinal decline in lung function were studied. A cohort of 171 pig farmers was followed over a 3-yr period. Long-term average exposure to dust and endotoxin was determined by personal monitoring in summer and winter, using data on farm characteristics and activities. Mean decline in FEV1 was 73 ml/yr and in FVC 55 ml/ yr. Long-term average exposure to dust was 2.63 mg/m3 (geometric SD [GSD] 1.30), and to endotoxin, 105 ng/m3 (GSD 1.5). Annual decline in FEV1 was significantly associated with endotoxin exposure. An increase in exposure with a factor 2 was associated with an extra decline of FEV1 of 19 ml/yr.
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Inhaled Endotoxin and Decreased Spirometric Values
Robert M. Castellan, Stephen A. Olenchock, Kathleen B. Kinsley et al. · New England Journal of Medicine · 1987 · 380 citations
Pharmacy, Immunology, Toxicology +13
Pulmonary Function and Symptoms after Inhalation of Endotoxin
Ragnar Rylander, Björn Bake, Janet J. Fischer et al. · American Review of Respiratory Disease · 1989 · 274 citations
Domestic endotoxin exposure and clinical severity of asthma
Olivier Michel, Roberta Ginanni, J. DUCHATEAU et al. · Clinical & Experimental Allergy · 1991 · 239 citations