Concepedia

FAK Activation and the Role of Epithelial Membrane Protein 2 (EMP2) in Collagen Gel Contraction

Shawn A. Morales, Sergey Mareninov, Madhuri Wadehra, Lily Zhang, Lee Goodglick, Jonathan Braun, Lynn K. Gordon

Investigative Ophthalmology & Visual Science · 2009 · 45 citations · 32 references

DOIFull text

Open access

Abstract

ARPE-19-mediated collagen gel contraction is a multistep process that requires integrin ligation and activation of the FAK/Src complex. EMP2 positively modulates collagen gel contraction by ARPE-19 cells through increased FAK activation.

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