Cytometry · 1990 · 109 citations · 61 references
Life SciencesGeneticsMolecular BiologyChromatin BiologyChromatin StructureDna ReplicationChromatinChromosome BiologyChromosome CondensationChromosome StructureDna PackagingMitosisChromatin ConfigurationChromatin PackagingChromosome Banding PatternsChromosome OrganizationEuchromatin TransitionsMatrix Attachment RegionsMetaphase Chromosome ArchitectureMitotic Chromosome Structure
A revised model of DNA packaging into chromosomes is presented. Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains. The transitions between euchromatic, heterochromatic and metaphase states are explained simply. Molecular and physical properties of chromosomal bands, and their correlation with specific DNA sequence motifs are discussed.
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D. Pinkel, J. E. Landegent, Colin C. Collins et al. · Proceedings of the National Academy of Sciences · 1988 · 1.3K citations · Full text
Topoisomerase II is a structural component of mitotic chromosome scaffolds.
William C. Earnshaw, Brian Halligan, Carol Cooke et al. · The Journal of Cell Biology · 1985 · 761 citations · Full text