In vitro characterisation of human renal and hepatic frusemide glucuronidation and identification of the UDP-glucuronosyltransferase enzymes involved in this pathway

HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID

Verawan Uchaipichat, Peter I. Mackenzie, Xiao-Hui Guo et al. · Drug Metabolism and Disposition · 2004 · 334 citations

Life Sciences, Biochemistry, Pharmacology +14

SELECTIVITY OF SUBSTRATE (TRIFLUOPERAZINE) AND INHIBITOR (AMITRIPTYLINE, ANDROSTERONE, CANRENOIC ACID, HECOGENIN, PHENYLBUTAZONE, QUINIDINE, QUININE, AND SULFINPYRAZONE) “PROBES” FOR HUMAN UDP-GLUCURONOSYLTRANSFERASES

Verawan Uchaipichat, Peter I. Mackenzie, David J. Elliot et al. · Drug Metabolism and Disposition · 2005 · 248 citations

Medicine, Biochemistry, Pharmacology +12

EVALUATION OF 3′-AZIDO-3′-DEOXYTHYMIDINE, MORPHINE, AND CODEINE AS PROBE SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 2B7 (UGT2B7) IN HUMAN LIVER MICROSOMES: SPECIFICITY AND INFLUENCE OF THE UGT2B7*2 POLYMORPHISM

Michael H. Court, Soundarajan Krishnaswamy, Qin Hao et al. · Drug Metabolism and Disposition · 2003 · 248 citations

Medicine, Biochemistry, Pharmacology +14

Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance

C. Ramana Bhasker, Wendy McKinnon, Andrew N. Stone et al. · Pharmacogenetics · 2000 · 246 citations

Life Sciences, Genetics, Molecular Genetics +13

In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance

Matthew G. Soars, Brian Burchell, Robert J. Riley · Journal of Pharmacology and Experimental Therapeutics · 2002 · 228 citations

Pharmacy, Pharmacokinetics, Pharmacology +17