Enzymatic resolution of racemic ibuprofen esters: Effects of organic cosolvents and temperature

Quantitative analyses of biochemical kinetic resolutions of enantiomers

Ching Shih Chen, Yoshitaka Fujimoto, Gary Girdaukas et al. · Journal of the American Chemical Society · 1982 · 2.6K citations

Charles J. Sihcite, Engineering, Chemical Analysis +19

Asymmetric transformations catalyzed by enzymes in organic solvents

Alexander M. Klibanov · Accounts of Chemical Research · 1990 · 965 citations

Engineering, Chemical Transformation, Chemical Analysis +16

General Aspects and Optimization of Enantioselective Biocatalysis in Organic Solvents: The Use of Lipases [New Synthetic Methods (76)]

Ching‐Shih Chen, Charles J. Sih · Angewandte Chemie International Edition in English · 1989 · 641 citations

Engineering, Enantioselective Biocatalysis, Enzymatic Modification +16

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

S. S. Adams, P. Bresloff, C. G. Mason · Journal of Pharmacy and Pharmacology · 1976 · 384 citations

A facile enzymatic resolution process for the preparation of (+)--2-(6-hethoxy-2-naphthyl)propionic acid (Naproxen).

Qu‐Ming Gu, Ching-Shin Chen, Charles J. Sih · Tetrahedron Letters · 1986 · 133 citations

Biochemistry, Natural Sciences, Biocatalysis +4