Efficient Access to Oseltamivir Phosphate (Tamiflu) via the <i>O‐</i>Trimesylate of Shikimic Acid Ethyl Ester

Abstract

The same azide intermediate as that used in the current technical synthesis of Tamiflu can be prepared in only eight steps and with only three workups; protecting group manipulations and chromatographic purification are not required. This approach includes a new protocol for aziridine formation to avoid competitive aromatization. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.