EI-1511-3, -5 and EI-1625-2, Novel Interleukin-1.BETA. Converting Enzyme Inhibitors Produced by Streptomyces sp. E-1511 and E-1625. I. Taxonomy of Producing Strain, Fermentation and Isolation.

Abstract

EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Streptomyces sp. E-1511 and E-1625. EI-1511-3, -5 and EI-1625-2 selectively inhibited the recombinant human ICE activity with IC50 values of 0.09, 0.38 and 0.2 microM, respectively. Taxonomy, fermentation of the producing strain and isolation of EI-1511-3, -5 and EI-1625-2 are described.