Publication | Closed Access
A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications
72
Citations
14
References
2013
Year
Bufalin 5β-HydroxylationMolecular BiologyKinetic CharacterizationChemical BiologyEnzymatic ModificationMolecular PharmacologySelective ProbeBioanalysisAnalytical ChemistryIsoform SelectivityBiochemistryBiocatalysisProbe ReactionCytochrome P450 3A4Natural SciencesEnzyme CatalysisChemical ProbeMedicineDrug DiscoveryHigh-throughput ScreeningDrug Analysis
Bufalin 5β-hydroxylation was found to be an isoform-specific biotransformation probe substrate for cytochrome P450 3A4 (CYP3A4). The probe reaction was well-characterized and it can be used for measuring the real catalytic activities of CYP3A4 from different enzyme sources.
| Year | Citations | |
|---|---|---|
Page 1
Page 1