Concepedia

A Novel Method for the Preparation of Macrolides from ω-Hydroxycarboxylic Acids

Isamu Shiina, Teruaki Mukaiyama

Chemistry Letters · 1994 · 64 citations · 14 references

DOI

Concepts

Abstract

Abstract An efficient method for the synthesis of macrolides directly from ω-hydroxycarboxylic acids is established by using 4-(trifluoromethyl)benzoic anhydride and a catalytic amount of active titanium(IV) salts together with chlorotrimethylsilane under mild conditions.

References

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