Concepedia

LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1α via upregulation of VHL in a colon cancer cell line

Kyeong Lee, Jung Eun Kang, Song‐Kyu Park, Yinglan Jin, Kyung‐Sook Chung, Hwan‐Mook Kim, Kiho Lee, Moo Rim Kang, Myung Kyu Lee, Kyung Bin Song,

Biochemical Pharmacology · 2010 · 149 citations · 35 references

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35

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O <sub>2</sub> Sensing

Mircea Ivan, Keiichi Kondo, Haifeng Yang et al. · Science · 2001 · 4.7K citations · Full text

, , +16

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Hua Zhong, Angelo M. De Marzo, Erik Laughner et al. · PubMed · 1999 · 2.2K citations

, , +14

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Susana Alicia Salceda, J. Jaime · Journal of Biological Chemistry · 1997 · 1.7K citations · Full text

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Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

Rajani Ravi, Bijoyesh Mookerjee, Zaver M. Bhujwalla et al. · PubMed · 2000 · 1.1K citations · Full text

, , +17