Oxyphil adenoma and primary hyperparathyroidism. Clinical and ultrastructral observations.

Abstract

A 65-year-old white man had hyperparathyroidism associated with an oxyphil adenoma. Review of the literature reveals this cell type to be a rare cause of parathyroid hyperactivity. Oxyphil cells have been considered inactive, or involutional forms. Electron microscopic examination of this tumor demonstrates well-defined organelles and membrane-limited secretory granules within the oxyphil cells suggesting a secretory function. The fine structure in oxyphil cells in normal parathyroid glands lacks such a well defined system. It is suggested that this tumor reflects an alteration of these cells resulting in the production of excess hormone secretion and clinical hyperparathyroidism.