Concepedia

Dichloromethane (methylene chloride): Metabolism to formaldehyde and formation of DNA-protein cross-links in B6C3F1 mice and Syrian Golden hamsters

Mercedes Casanova, Donald F. Deyo, Henry d’A. Heck

Toxicology and Applied Pharmacology · 1992 · 32 citations · 21 references

DOI

Concepts

References

21

Physiologically based pharmacokinetics and the risk assessment process for methylene chloride

Melvin E. Andersen, Harvey J. Clewell, Michael L. Gargas et al. · Toxicology and Applied Pharmacology · 1987 · 634 citations

, , +10

Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways

Michael L. Gargas, Harvey J. Clewell, Melvin E. Andersen · Toxicology and Applied Pharmacology · 1986 · 166 citations

, , +16

Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacolinetics, rat-to-monkey interspecies scaling, and extrapolation to man

M. Casanova · Fundamental and Applied Toxicology · 1991 · 150 citations

, , +17

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

Dean P. Jones, Hjördis Thor, Bo Andersson et al. · Journal of Biological Chemistry · 1978 · 148 citations · Full text

, , +17

In vitro metabolism of methylene chloride in human and animal tissues: Use in physiologically based pharmacokinetic models

Richard H. Reitz, Alan L. Mendrala, F. Peter Guengerich · Toxicology and Applied Pharmacology · 1989 · 138 citations

, , +9