Complete Response of Multiple Melanoma Brain Metastases after Treatment with Temozolomide

Abstract

BACKGROUND: Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare. CASE REPORT: A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance. CONCLUSIONS: The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.