Chloroquine protects mice from challenge with CpG ODN and LPS by decreasing proinflammatory cytokine release

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai et al. · Nature · 2000 · 6.4K citations

Life Sciences, Immunology, Microbiology +13

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Life Sciences, Genetics, Immunology +15

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

Adrian Ozinsky, David M. Underhill, Jason D. Fontenot et al. · Proceedings of the National Academy of Sciences · 2000 · 2.1K citations · Full text

Life Sciences, Immunology, Microbiology +17

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

Veit Hornung, Simon Rothenfußer, Stefanie Britsch et al. · The Journal of Immunology · 2002 · 1.9K citations

Life Sciences, Immunology, Molecular Biology +12

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

Koichi S. Kobayashi, Lorraine D. Hernandez, Jorge E. Galán et al. · Cell · 2002 · 1.3K citations · Full text

Life Sciences, Cell Biology, Immunology +14