Synthesis and preliminary pharmacological evaluation of imidazo[2,1-f]purine-2,4-dione derivatives

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J E Leysen, C. J. E. Niemegeers, Jan M. Van Nueten et al. · Molecular Pharmacology · 1982 · 1.1K citations

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Derek N. Middlemiss, John R. Fozard · European Journal of Pharmacology · 1983 · 869 citations

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7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.

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