Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors

Kevin D. Burris, Thaddeus F. Molski, Cen Xu, +5

Journal of Pharmacology and Experimental Therapeutics

The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor

Shaun Jordan, Vuk Koprivica, Ruoyan Chen, +3

European Journal of Pharmacology

Psychoactive DrugPsychiatryFunctional SelectivityHuman 5-Ht1a ReceptorMedicine +7

7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity.

Tetsuro Kikuchi, Katsura Tottori, Yasufumi Uwahodo, +4

Journal of Pharmacology and Experimental Therapeutics

Novel Antipsychotic Agents with Dopamine Autoreceptor Agonist Properties:  Synthesis and Pharmacology of 7-[4-(4-Phenyl-1-piperazinyl)butoxy]-3,4-dihydro-2(1<i>H</i>)-quinolinone Derivatives

Yasuo Oshiro, Seiji Sato, Nobuyuki Kurahashi, +5

Journal of Medicinal Chemistry

Dopa SynthesisGbl-induced Dopa SynthesisPsychotropic MedicationPsychopharmacologyPharmacotherapy +17

In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function

Shaun Jordan, Vuk Koprivica, Robert W. Dunn, +3

European Journal of Pharmacology

NeuropsychologyPsychoactive DrugNeurophysiologyAddictionMedicine +11

3,4-Dihydro-2(1<i>H</i>)-quinolinone as a Novel Antidepressant Drug:  Synthesis and Pharmacology of 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1<i>H</i>)-quinolinone and Its Derivatives

Yasuo Oshiro, Yoji Sakurai, Seiji Sato, +7

Journal of Medicinal Chemistry

PsychopharmacologyPharmacotherapyHeterocycle ChemistryExperimental PharmacologyNovel Antidepressant Drug +17

Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic

Yoshihiro Tadori, Takashi Miwa, Katsura Tottori, +4

European Journal of Pharmacology

Psychoactive DrugPsychiatryAddictionD2s ReceptorsMedicine +10

The novel antipsychotic aripiprazole is a partial agonist at short and long isoforms of D2 receptors linked to the regulation of adenylyl cyclase activity and prolactin release

Koutoku Aihara, Jun Shimada, Takashi Miwa, +4

Brain Research

PsychiatryNovel Antipsychotic AripiprazolePharmacologyPsychopharmacologyPharmacological Agent +5

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523

Katsura Tottori, Takashi Miwa, Yasufumi Uwahodo, +5

Neuropharmacology

PsychiatryMood SymptomMedicinePsychotropic MedicationFunctional Selectivity +9

Diminished catalepsy and dopamine metabolism distinguish aripiprazole from haloperidol or risperidone

Satoru Nakai, Tsuyoshi Hirose, Yasufumi Uwahodo, +11

European Journal of Pharmacology

Psychoactive DrugPsychiatryMedicinePsychopharmacologySchizophrenia +5