Two Drimane-type Sesquiterpenes, Strobilactones A and B, from the Liquid Culture of the Edible Mushroom Strobilurus ohshimae

Abstract

Two novel drimane sesquiterpenoids, strobilactones A (3) and B (4), were isolated fromthe organic extract of a liquid culture of Strobilurus ohshimae. The structures of 3 and 4 were determined by spectroscopic methods. Compounds 3 and 4 exhibit cell growth inhibitory activities against cultured COLO 201 cells. Compound 4 also shows antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa.