Protein phylogenies provide evidence of a radical discontinuity between arthropod and vertebrate immune systems

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

Naruya Saitou, M Nei · Molecular Biology and Evolution · 1987 · 60.5K citations · Full text

Life Sciences, Bioinformatics, Evolutionary Biology +17

CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP

Joseph Felsenstein · Evolution · 1985 · 41.5K citations · Full text

Life Sciences, Biostatistics, Evolutionary Biology +10

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Life Sciences, Immunology, Molecular Biology +13

The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults

Bruno Lemaître, Émmanuelle Nicolas, Lydia Michaut et al. · Cell · 1996 · 4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

CLUSTAL V: improved software for multiple sequence alignment

Desmond G. Higgins, Alan J. Bleasby, Rainer Fuchs · Computer applications in the biosciences · 1992 · 2.4K citations · Full text

Life Sciences, Bioinformatics, Molecular Evolution +12