Perkin communications. Synthesis of 3-amino-4-phenylpyridines: a novel strategy for the preparation of<scp>CD</scp>ring models of streptonigrin

Abstract

An efficient synthesis of 3-amino-4-phenylpyridine derivatives is reported. 3-Pivaloylaminopyridines were lithiated by butyl-lithium before reaction with iodine as electrophile to afford 4-iodo-3-pivaloylaminopyridines. Cross-coupling of the latter with suitable phenylboronic acids gives CD ring models of streptonigrin.