A simple and eco-sustainable method for the<i>O</i>-Boc protection/deprotection of various phenolic structures under water-mediated/catalyst-free conditions

Abstract

A greener, efficient, and chemoselective protocol for O-Boc protection/deprotection of a wide range of phenol derivatives is reported under catalyst-free conditions in water-related systems. Unlike previous reports, no additional reagents or catalysts were used, and workup fulfils green chemistry requirements, making the present method even more interesting.