Long-term analgesic effect of a single dose of anti-NGF antibody on pain during motion without notable suppression of joint edema and lesion in a rat model of osteoarthritis

Opioid Complications and Side Effects

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Medicine, Pharmacology, Pharmacotherapy +14

p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

Ru‐Rong Ji, Tarek A. Samad, Shan‐Xue Jin et al. · Neuron · 2002 · 1.2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

Tanezumab for the Treatment of Pain from Osteoarthritis of the Knee

Nancy E. Lane, Thomas J. Schnitzer, C. Birbara et al. · New England Journal of Medicine · 2010 · 672 citations · Full text

Medicine, Orthopedic Surgery, Pharmacotherapy +17

Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis

Yasuhiro Indo, Motoko Tsuruta, Yumi Hayashida et al. · Nature Genetics · 1996 · 639 citations · Full text

Life Sciences, Genetics, Neuroscience +10

Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

John Bradley, Kenneth D. Brandt, Barry P. Katz et al. · New England Journal of Medicine · 1991 · 629 citations

Medicine, Orthopaedic Surgery, Pharmacotherapy +17