Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells

Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

Naoufal Zamzami, Philippe Marchetti, Maria Castedo et al. · The Journal of Experimental Medicine · 1995 · 1.2K citations · Full text

Life Sciences, Cell Biology, Immunology +14

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

Charles E. Myers, William P. McGuire, Robert H. Liss et al. · Science · 1977 · 1.1K citations

Medicine, Oncology, Pharmacology +16

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

James H. Doroshow, Kelvin J.A. Davies · Journal of Biological Chemistry · 1986 · 549 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

April C. Childs, Sharon Phaneuf, Amie J. Dirks et al. · PubMed · 2002 · 452 citations

Medicine, Cardiology, Pharmacology +7

Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice

Zhongyi Chen, Chu Chang Chua, Ye‐Shih Ho et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2001 · 410 citations

Life Sciences, Cardiology, Molecular Biology +13