Journal of Natural Products · 1985 · 22 citations · 0 references
MedicineBotanyPlant SciencesHemostasisPlant BiochemistryPlant PhysiologyHemostatic AgentsMedicinal PlantsPlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyAdenosine Diphosphate-induced Platelet AggregationAntiplatelet DrugsArachidonic Acid SignalingCollagen-induced Platelet ActivationCollagen-induced Platelet AggregationPlatelet Aggregation InhibitionPlatelet Inhibition
The smear method developed by Velaskar and Chitre was modified to allow the massive screening of plant extracts and/or fractions for platelet antiaggregating activity. Aspirin and papaverine, known inhibitors of platelet aggregation, were tested by the modified method and showed comparable results with previously reported data. Fifty-four fractions prepared from eighteen plant species were screened for their inhibitory effects on adenosine 5'-diphosphate, arachidonic acid, or collagen-induced rat platelet aggregation. The results suggest that plants could be a potential source of inhibitors of platelet aggregation.