A combined electrophilic diazo and nucleophilic azide transfer reaction for the efficient conversion of an N-hydroxy-β-lactam to a carbacephem precursor

46th Interscience Conference on Antimicrobial Agents and Chemotherapy

John McConnell · The Lancet Infectious Diseases · 2006 · 543 citations

Life Sciences, Infectious Diseases, Microbiology +14

The asymmetric synthesis of β-lactam antibiotics -II. The first enantioselective synthesis of the carbacephalosporin nucleus.

David A. Evans, Eric B. Sjogren · Tetrahedron Letters · 1985 · 86 citations

Pharmacy, Medicinal Chemistry, Drug Discovery +10

Total synthesis of .beta.-lactam antibiotics. VIII. Stereospecific total synthesis of (+-)-1-carbacephalothin

R. N. GUTHIKONDA, L. D. Cama, B. G. CHRISTENSEN · Journal of the American Chemical Society · 1974 · 85 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Enantioselective acylation of a beta-lactam intermediate in the synthesis of loracarbef using penicillin G amidase

Milton J. Zmijewski, Barbara Briggs, Allen R. Thompson et al. · Tetrahedron Letters · 1991 · 80 citations

Natural Sciences, Chemistry, Medicinal Chemistry +13

Total synthesis of .beta.-lactam antibiotics. Epimerization of 6(7)-aminopenicillins and cephalosporins from .alpha. to .beta.

Raymond A. Firestone, Natalie S. Maciejewicz, Ronald W. Ratcliffe et al. · The Journal of Organic Chemistry · 1974 · 62 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10