Concepedia

Cysteamine Suppresses Invasion, Metastasis and Prolongs Survival by Inhibiting Matrix Metalloproteinases in a Mouse Model of Human Pancreatic Cancer

Toshio Fujisawa, Benjamin Rubin, Akiko Suzuki, Prabhudas S. Patel, William A. Gahl, Bharat Joshi, Raj K. Puri

PLoS ONE · 2012 · 52 citations · 32 references

DOIFull text

Open access

Abstract

Our results suggest that cysteamine, an agent with a proven safety profile, may be useful for inhibition of metastasis and prolonging the survival of a host with pancreatic cancer.

References

32

Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.

Barbara Schmalfeldt, Dieter Prechtel, Kathrin Härting et al. · PubMed · 2001 · 336 citations

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Improved Renal Function in Children with Cystinosis Treated with Cysteamine

Thomas C. Markello, Isa Bernardini, William A. Gahl · New England Journal of Medicine · 1993 · 284 citations · Full text

Randomized Phase III Trial of Marimastat Versus Placebo in Patients With Metastatic Breast Cancer Who Have Responding or Stable Disease After First-Line Chemotherapy: Eastern Cooperative Oncology Group Trial E2196

Joseph A. Sparano, Patricia Bernardo, Patricia Stephenson et al. · Journal of Clinical Oncology · 2004 · 261 citations · Full text

Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).

S. A. Eccles, G. Box, William Court et al. · PubMed · 1996 · 193 citations

, , +17

Authentic Matrix Vesicles Contain Active Metalloproteases (MMP)

Marina D’Angelo, Paul C. Billings, Maurizio Pacifici et al. · Journal of Biological Chemistry · 2001 · 192 citations · Full text