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Substitution of the transmembrane domain of Vpu in simian–human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques

Virus StructureMolecular VirologyMedicineTransmembrane DomainViral PathogenesisImmunologyImmunodominanceVirologyAntiviral ResponsePig-tailed MacaquesMicrobiologyHivImmune SystemM2 Ion ChannelViral Structural ProteinViral Immunity