Efficient Synthesis of 2-Methylene-3phosphorylalkanoates: Phosphorylation of Baylis–Hillman Bromides via an S_<i>N</i>2-S_<i>N</i>2′ Strategy

Abstract

A novel synthesis of 2-methylene-3-phosphorylalkanoates under mild conditions is described. Thus, Balyis–Hillman bromides react with secondary phosphine oxides or H-phosphonites in the presence of DABCO via an S N 2-S N 2′ protocol to produce the target compounds in good yields.