Human pulmonary alveolar macrophages metabolise benzo(a)pyrene to proximate and ultimate mutagens

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

Eliezer Huberman, Leo Sachs, Shen K. Yang et al. · Proceedings of the National Academy of Sciences · 1976 · 480 citations · Full text

Pharmacy, Toxicology, Carcinogenesis +16

Cell‐mediated mutagenesis of mammalian cells with chemical carcinogens

Eliezer Huberman, Leo Sachs · International Journal of Cancer · 1974 · 243 citations

Medicine, Toxicology, Biochemical Toxicology +10

Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

Jaime Kapitulnik, Wayne Levin, Allan H. Conney et al. · Nature · 1977 · 208 citations

Medicine, Toxicology, Carcinogenesis +10

High-pressure liquid chromatographic analysis of benzo(alpha)pyrene metabolism and covalent binding and the mechanism of action of 7,8-benzoflavone and 1,2-epoxy-3,3,3-trichloropropane.

James K. Selkirk, Robert G. Croy, Peter P. Roller et al. · PubMed · 1974 · 171 citations

Pharmacy, Pharmacology, Chromatographic Analysis +14

Induction of Aryl Hydrocarbon Hydroxylase in Human Pulmonary Alveolar Macrophages by Cigarette Smoking

Elroy T. Cantrell, G A Warr, David L. Busbee et al. · Journal of Clinical Investigation · 1973 · 155 citations · Full text

Life Sciences, Biochemistry, Toxicology +11